HOMEWORK HELP | Based on your knowledge of epigenetics and what you learned in BIO151 (or other Cell & Mol class) about regulation of the cell cycle, can you explain what’s the rationale of the treatment for Wiggles?

5. Wiggles is a golden retriever that has been diagnosed with lymphoma. After visiting the Vet, the course of action is to give Wiggles a treatment based on HDACi (histone deacetylase inhibitors), a drug called Xyzi. This decision is based on the data shown in the graph below (Fig. 1): Relative Expression of p21 0 1.4 UM 0.06 UM 0.28 UM Treatment Figure 1: Expression of gene p21 in relation to the dose of the drug Xyzi. Based on your knowledge of epigenetics and what you learned in BIO151 (or other Cell & Mol class) about regulation of the cell cycle, can you explain what’s the rationale of the treatment for Wiggles? In other words, what’s wrong with him (what’s causing the cancer) and how this treatment is going to help him get better? Note that you may need to do some extra reading to answer to this question. [4 pts]